In 2023, Task Force 141 faces its greatest challenge yet. Following the death of General Shepherd and the exposure of Shadow Company's betrayal, Captain Price and his team are thrust into a new crisis. The remnants of the Ultranationalists, led by the cunning Makarov, are on the rise, threatening global stability with a series of coordinated terrorist attacks.

As Makarov's influence spreads, Task Force 141 must track him across multiple continents, uncovering his connections to various criminal and terrorist organizations. The stakes are higher than ever, with Makarov orchestrating devastating assaults on major cities, aiming to ignite a global conflict.

Task Force 141, joined by new allies and old friends, must thwart Makarov's plans while dealing with internal conflicts and the fallout from previous missions. The journey takes them from the streets of New York to the deserts of the Middle East, and into the heart of Russia, culminating in a final showdown to stop Makarov and restore peace.